Quantitative ultrasound and apoptotic death in the neonatal primate brain
نویسندگان
چکیده
منابع مشابه
Neonatal Hypoxic-Ischemic Brain Injury: Apoptotic and Non- Apoptotic Cell Death
The neuronal cell death associated with perinatal asphyxia, or hypoxicischemic (HI) brain injury, plays an important role in neonatal mortality and neurodevelopment retardation. The types of cell death associated with HI in the brain have been classified as being either apoptotic or necrotic. Here we describe the recent discoveries of multiple non-apoptotic cell death pathways: necroptosis; fer...
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BACKGROUND Magnesium sulfate (MgSO4) is often used as a treatment for pre-eclampsia/eclampsia and preterm labor, resulting in the exposure of a significant number of neonates to this drug despite a lack of evidence suggesting that it is safe, or effective as a tocolytic. While there is evidence that MgSO4 may be neuroprotective in perinatal brain injury, recent reviews have suggested that the e...
متن کاملApoptotic mechanisms in the neonatal brain following hypoxia-ischemia
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متن کاملNon-human primate models of neonatal brain injury.
Nonhuman primate species have been selectively used in the scientific investigation of adult and newborn neurological diseases. The rhesus monkey has been utilized in models of term asphyxial insults, accurately reflecting the mechanisms and neuropathology demonstrated in the newborn human infant. More recently, a premature baboon model developed for evaluation of bronchopulmonary dysplasia has...
متن کاملLow-frequency quantitative ultrasound imaging of cell death in vivo.
PURPOSE Currently, no clinical imaging modality is used routinely to assess tumor response to cancer therapies within hours to days of the delivery of treatment. Here, the authors demonstrate the efficacy of ultrasound at a clinically relevant frequency to quantitatively detect changes in tumors in response to cancer therapies using preclinical mouse models. METHODS Conventional low-frequency...
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ژورنال
عنوان ژورنال: Neurobiology of Disease
سال: 2019
ISSN: 0969-9961
DOI: 10.1016/j.nbd.2019.03.032